According to the involved Nidana as Rajayakshma devided as Sahasajanya Rajayakshma, Vega Sandarana janya Rajayakshma, Kshaya janya Rajayakshma, and Vishamashana janya Rajayakshma. Conclusion-Rajayakshma is an unique disease the classification of disease has been don on the base of Nidana and Samprapti. Materials and Methods: In this study Ayurveda elementary books were thoroughly searched to compile information about rajayakhma to evaluate the nidana and samprapti of the disease. To understand this concept and utilize it thoroughly in planning the proper treatment for rajayakshma. Aims and Objectives: To enlighten the basic concept of nidana and samprapti of rajayakshma to its full perspective. Chikitsa is nothing but the Nidana Parivarjana and Samprapti Vighatana. understanding Chikitsa the knowledge of nidana and the samprati is very necessary. Ayurveda classics gives importance to Nidana because it is a Sarva Tantra Siddanta that effect will always be going to imitate the cause i.e. Due to indulging in Sahasa, Vega Sandarana, Kshaya, Vishamashana, there is the manifestation of Ekadasha Rupa where it affects the Tridosha and Sapta Dhatu. Rajayakshma is a Madhyama Rogamarga Vyadhi manifested Shosha.
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